Are Hemochromatosis Mutations Protective Against Iron-Mediated Atherogenesis?
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Do Hemochromatosis Mutations Protect Against Iron-Mediated Atherogenesis?
It has been proposed that modest levels of stored iron, far less than conventional iron overload, promote cardiovascular disease and that sustained iron depletion is protective against it.1– 6 This so-called “iron hypothesis” was initially presented as an explanation for the sex difference in cardiovascular disease and the increase in disease after menopause. The idea, although continually deba...
متن کاملLetter by ryan et Al regarding article, "do hemochromatosis mutations protect against iron-mediated atherogenesis?".
It has been proposed that modest levels of stored iron, far less than conventional iron overload, promote cardiovascular disease and that sustained iron depletion is protective against it.1– 6 This so-called “iron hypothesis” was initially presented as an explanation for the sex difference in cardiovascular disease and the increase in disease after menopause. The idea, although continually deba...
متن کاملHemochromatosis associated with endothelial dysfunction: evidence for the role of iron stores in early atherogenesis.
Impaired endothelium-dependent, flow-mediated dilatation of the brachial artery was observed in a 50-year-old premenopausal female non-smoker with idiopathic hemochromatosis. Endothelial dysfunction observed in this patient supports a relationship between body iron stores and early atherosclerotic process.
متن کاملHemochromatosis gene mutations and iron metabolism in celiac disease.
BACKGROUND AND OBJECTIVES Iron deficiency anemia is a common manifestation of celiac disease, which may be due to genetic and environmental factors. HFE mutations, frequent in Caucasian populations, can cause increased intestinal iron absorption and thus could protect against the development of iron deficiency. The aim of this study was to evaluate the prevalence of HFE mutations and their effe...
متن کاملCurrent approach to hereditary hemochromatosis
Hereditary hemochromatosis refers to several inherited disorders of the iron metabolism that lead to tissue iron overload. Classical hereditary hemochromatosis is associated with mutations of the HFE gene (C282Y homozygotes or C282Y/H63D compound heterozygotes) and is almost exclusively found in populations of northern European descent. Non-HFE-associated hereditary hemochromatosis is caused by...
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تاریخ انتشار 2017